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Toxic Exposure & PACT Act
2025-05-27· 4 min read

Agent Orange Presumptive Conditions: 2026 List

The full, current list of presumptive conditions for Agent Orange exposure, including the PACT Act additions like hypertension, plus every qualifying service location and period.

By VA Benefits Help Guide Editorial Team · Updated 2026-06-01
Quick answer

Agent Orange presumptive conditions include type 2 diabetes, ischemic heart disease, Parkinson's disease, prostate cancer, multiple myeloma, chronic B-cell leukemias, hypertension (added under the PACT Act), and several other cancers and conditions.

Agent Orange presumptive coverage has expanded substantially since it was first established in 1991. The PACT Act added hypertension and monoclonal gammopathy of undetermined significance (MGUS) in 2022, bringing the list to its largest scope to date — and it's worth checking against even if you were previously told you didn't qualify.

Presumptive Conditions

  • AL Amyloidosis
  • Bladder cancer
  • Chronic B-cell leukemias
  • Chloracne
  • Diabetes mellitus type 2
  • Hodgkin's disease
  • Hypertension (PACT Act addition)
  • Hypothyroidism
  • Ischemic heart disease
  • Monoclonal gammopathy of undetermined significance (MGUS) — PACT Act addition
  • Multiple myeloma
  • Non-Hodgkin's lymphoma
  • Parkinsonism and Parkinson's disease
  • Peripheral neuropathy (early-onset)
  • Porphyria cutanea tarda
  • Prostate cancer
  • Respiratory cancers (lung, larynx, trachea, bronchus)
  • Soft tissue sarcomas

Denied before 2022 for a condition that's now presumptive?

Re-File an Old Denial

Where Service Counts

  • Vietnam, January 9, 1962 through May 7, 1975 — including inland waterways and territorial seas under the Blue Water Navy expansion
  • Korean DMZ, September 1, 1967 through August 31, 1971
  • Certain Thailand military bases during the Vietnam era
  • C-123 aircraft crew service, 1969 through 1986, exposed through post-war aircraft contamination

Why the Hypertension Addition Is a Bigger Deal Than It Sounds

Hypertension is extraordinarily common and has many possible causes, which made it nearly impossible to service-connect through direct causation before it became presumptive — a rater could always point to another plausible cause. Now, qualifying service plus a current hypertension diagnosis is enough on its own, which has opened the door for a large number of Vietnam-era veterans previously denied for exactly this reason.

Frequently asked questions

Conclusion

The Agent Orange presumptive list keeps growing — if you served in any covered location and have any condition on this list, the path to service connection is short, and it's worth re-filing even an old denial.

Denied before 2022 for a condition that's now presumptive?

Re-File an Old Denial

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Educational only. Not legal advice. Verify with the VA or an accredited representative.